An overdose of Lexapro, an SSRI antidepressant, occurs when an individual ingests an excessive amount, leading to serious health risks. Overdose severity ranges from mild to life-threatening, involving symptoms like agitation, confusion, serotonin syndrome, and heart rhythm disturbances. Emergency medical services and hospital care are crucial for management, and the FDA plays a vital role in regulating Lexapro’s safety. Prevention strategies, including responsible use and proper medication storage, are essential to avoid overdoses.